A Versatile Protocol for Studying Calvarial Bone Defect Healing in a Mouse Model
نویسندگان
چکیده
منابع مشابه
TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice
BACKGROUND Toll-like receptor 4 (TLR4) has been implicated in inflammation-induced bone destruction in various chronic bone diseases; however, its direct influence on bone healing is not well understood. The authors' previous study showed accelerated bone healing with higher osteoclastogenesis gene expression in toll-like receptor 4 knockout mice (TLR4). This study aimed to further elucidate th...
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Scaffold-mediated gene delivery holds great promise for tissue regeneration. However, previous attempts to induce bone regeneration using scaffold-mediated non-viral gene delivery rarely resulted in satisfactory healing. We report a novel platform with sustained release of minicircle DNA (MC) from PLGA scaffolds to accelerate bone repair. MC was encapsulated inside PLGA scaffolds using supercri...
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ژورنال
عنوان ژورنال: Tissue Engineering Part C: Methods
سال: 2017
ISSN: 1937-3384,1937-3392
DOI: 10.1089/ten.tec.2017.0205